Table 1.
Parameters used in the model
| Parameter | Description |
|---|---|
| nF | Density of wild-type/plasmid-free cells ('F' in figures) |
| nC | Density of cells with resistance on the chromosome ('C' in figures) |
| nP | Density of cells infected with a resistance-carrying plasmid ('Plasmids' in figures) |
| nB | Density of cells infected with a non-coding plasmid ('B' in figures) |
| nCP | Density of cells with resistance both on the chromosome and on a plasmid ('CP' in figures) |
| nCB | Density of cells infected with a non-coding plasmid, and with resistance on the chromosome ('CB' in figures) |
| N | Total density of cells N = nF+nC+nP+nB+nCP+nCB |
| A | Concentration of antibiotic |
| l | Rate of decay of antibiotic |
| θ | Treatment dosage of antibiotic |
| τ | Interval between antibiotic treatments |
| r | Intrinsic per-capita growth rate of cells |
| a | Extrinsic density-dependent death rate of cells |
| m | Death rate of non-resistant cells, due to antibiotic |
| cC | Cost of antibiotic resistance when gene carried on chromosome |
| cP | Cost of antibiotic resistance when gene carried on plasmid |
| x | Cost of plasmid carriage |
| β | Rate of horizontal transfer of plasmids |
| s | Rate of segregation |