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. 2001 Mar 27;98(7):4078–4083. doi: 10.1073/pnas.061004098

Figure 1.

Figure 1

TFPI secretion in canine VSMC. Human TFPI was measured by the ELISA in the conditioned medium of dog VSMC. (a) Time course of TFPI (in ng/106 cells/24 h) secreted by VSMC infected for 6 h with Ad-TFPI or Ad-RR (identical construct minus the foreign gene) at moi 500 (see Methods). (b) Viral dose response of TFPI secretion in VSMC (ng/106 cells/24 h) 4 days after a 6-h infection with Ad-TFPI. No TFPI was detected in VSMC infected with Ad-RR. (c) Anti-TF/factor VIIa activity of human TFPI secreted by dog VSMC. TFPI activity in the conditioned medium is expressed in TFPI units (where 1 unit corresponds to about 55 ng TFPI in human plasma; see Methods).