Figure 2.

TFPI gene transfer in balloon-injured atherosclerotic rabbit arteries and TFPI immunoreactivity in normal rabbit endothelium. Atherosclerotic carotid plaque of a Watanabe rabbit killed 4 days after infection with Ad-TFPI at 1 × 10¹⁰ pfu/ml (see Methods). (a) Immunostain for human TFPI. (b) The TFPI antibody used in a is replaced with an unrelated (cytomegalovirus) control antibody in an adjacent section; c and d show endothelium, respectively, of the carotid artery and s.c. microvasculature of a normal New Zealand White rabbit killed without prior injury. Tissue sections were immunostained with the antibody recognizing human TFPI. a and b, ×200; c, ×400; d, ×100.