Table 2.
Whole blood aggregation of Watanabe rabbits treated locally with Ad-TPFI (n = 10) and Ad-RR (n = 9)
| Aggregation, %
|
|||||
|---|---|---|---|---|---|
| Collagen,
μ/ml
|
Thrombin, units/ml
|
||||
| 5 | 10 | .125 | .25 | .5 | |
| Ad-RR | |||||
| Day 0 | 33 ± 12 | 52 ± 9 | 30 ± 29 | 65 ± 21 | 92 ± 16 |
| Day 7 | 38 ± 16 | 50 ± 24 | 21 ± 28 | 86 ± 22 | 86 ± 23 |
| Ad-TFP | |||||
| Day 0 | 27 ± 8 | 44 ± 15 | 10 ± 14 | 57 ± 25 | 89 ± 15 |
| Day 7 | 37 ± 10 | 47 ± 20 | 18 ± 2 | 92 ± 34 | 102 ± 27 |
Whole blood aggregation (%) was measured as electrical impedance (ohms) in a Chrono-Log aggregometer (Chrono-Log Corporation, Havertown, PA) before injury (day 0) and after 7 days. Blood was drawn into heparin (2 units/ml) for aggregation to collagen (Hormon Chemie, Munich) or into 3.8% sodium citrate (1:9 = vol/vol) for aggregation to α/β thrombin (Fibrindex, Ortho-McNeil Pharmaceutical, Raritan, NJ).