Table 3.
Dissimilar genes between E. coli and S. aureus infections in cattle
| Gene | Gene Name | E. coli shrunken centroid | S. aureus shrunken centroid |
|---|---|---|---|
| ABCG2 | ATP-binding cassette, sub-family G WHITE, member 2 | -1.007 | 0.671 |
| IDH1 | Isocitrate dehydrogenase 1 NADP+, soluble | -0.929 | 0.619 |
| AGPAT1 | 1-acylglycerol-3-phosphate O-acyltransferase 1 lysophosphatidic acid acyltransferase, alpha | -0.894 | 0.596 |
| PCGF1 | Polycomb group ring finger 1 | -0.795 | 0.53 |
| GALNTL4 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4 | -0.52 | 0.346 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.496 | 0.33 |
| TMEM164 | Transmembrane protein 164 | -0.42 | 0.28 |
| RHOF | Ras homolog gene family, member F | -0.391 | 0.261 |
| MFSD4 | Major facilitator superfamily domain containing 4 | -0.263 | 0.175 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | -0.217 | 0.145 |
| FEZ1 | Fasciculation and elongation protein zeta 1 zygin I | -0.204 | 0.136 |
| PAOX | Polyamine oxidase exo-N4-amino | -0.154 | 0.103 |
| PMEPA1 | Prostate transmembrane protein, androgen induced 1 | -0.106 | 0.07 |
| HIGD1B | HIG1 hypoxia inducible domain family, member 1B | -0.134 | 0.089 |
| DNAJC12 | DnaJ Hsp40 homolog, subfamily C, member 12 | -0.132 | 0.088 |
| VWF | Von Willebrand factor | -0.131 | 0.088 |
| KIAA1467 | KIAA1467 | -0.131 | 0.087 |
| SENP2 | SUMO1/sentrin/SMT3 specific peptidase 2 | -0.068 | 0.046 |
| IGFBP5 | Insulin-like growth factor binding protein 5 | -0.06 | 0.04 |
| SCP2 | Sterol carrier protein 2 | -0.018 | 0.012 |
| NPAL2 | NIPA-like domain containing 2 | -0.009 | 0.006 |
| LRRN3 | Leucine rich repeat neuronal 3 | 0.732 | -0.488 |
| FKBP5 | FK506 binding protein 5 | 0.7 | -0.466 |
| SLC38A7 | Solute carrier family 38, member 7 | 0.641 | -0.427 |
| HSPD1 | Heat shock 60 kDa protein 1 chaperonin | 0.56 | -0.373 |
| GLUL | Glutamate-ammonia ligase glutamine synthetase | 0.352 | -0.235 |
| CSDA | Cold shock domain protein A | 0.174 | -0.116 |
| INO80E | INO80 complex subunit E | 0.142 | -0.095 |
| SAT1 | Spermidine/spermine N1-acetyltransferase 1 | 0.118 | -0.079 |
| PHB | Prohibitin | 0.075 | -0.05 |
| STAT3 | Signal transducer and activator of transcription 3 acute-phase response factor | 0.061 | -0.04 |
| MAX | MYC associated factor X | 0.051 | -0.034 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.033 | -0.022 |
| LCN2 | Lipocalin 2 | 0.024 | -0.016 |
List of the 34 most dissimilarly regulated genes identified with the PAMR software, showing opposite fold change responses during E. coli and S. aureus infections in cattle in vivo (experiment 1A, B, and C). For each gene, the PAMR shrunken centroid values (using a threshold parameter of 3.77) for the E. coli and the S. aureus experiments are reported. Twenty-one of the listed genes were up-regulated during infection with S. aureus, while 13 were up-regulated during E. coli infection.