Table 5.
Top-20 target rankings by compound count and molecular frameworks.
| Cmpd ranking | Target symbol | MF2 ranking | Target symbol | GS ranking | Target symbol |
|---|---|---|---|---|---|
| 1 | F10 | 1 | F10 | 1 | F10 |
| 2 | CNR1 | 7 | HRH3 | 7 | HRH3 |
| 3 | KDR | 2 | CNR1 | 3 | KDR |
| 4 | MAPK14 | 6 | F2 | 6 | F2 |
| 5 | DRD3 | 3 | KDR | 2 | CNR1 |
| 6 | F2 | 5 | DRD3 | 24 | OPRM1 |
| 7 | HRH3 | 28 | CTSS | 20 | MC4R |
| 8 | TACR1 | 8 | TACR1 | 5 | DRD3 |
| 9 | MMP13 | 10 | CNR2 | 8 | TACR1 |
| 10 | CNR2 | 12 | ADORA2A | 29 | CHRM3 |
| 11 | MMP1 | 4 | MAPK14 | 28 | CTSS |
| 12 | ADORA2A | 29 | CHRM3 | 26 | REN |
| 13 | EGFR | 9 | MMP13 | 10 | CNR2 |
| 14 | SLC6A4 | 26 | REN | 4 | MAPK14 |
| 15 | MMP9 | 24 | OPRM1 | 12 | ADORA2A |
| 16 | HTR6 | 23 | CCR3 | 31 | DRD2 |
| 17 | MMP2 | 20 | MC4R | 38 | MCHR1 |
| 18 | HTR2C | 17 | MMP2 | 37 | SRC |
| 19 | CRHR1 | 11 | MMP1 | 16 | HTR6 |
| 20 | MC4R | 25 | DPP4 | 49 | ELANE |
Columns 1 and 2 are the compound count ranking, columns 3 and 4 show the molecular framework 2 (MF2) ranking and colums 5 and 6 show the graph scaffold (GS) ranking.