Mean serum IGF‐1 (A), GH (B), glucose (C), insulin (D) (n = 5 per group), and osteocalcin (E) (n = 8 per group) levels (±SD) for male and female control and ALSKO mice at 4, 8, and 16 weeks of age. §
ALSKO females have significantly reduced IGF‐1 levels compared with both male and female controls at 4 weeks. *ALSKO males and females have significantly reduced IGF‐1 levels compared to their respective controls at 8 and 16 weeks. †
ALSKO males have reduced osteocalcin compared with male controls. ‡
ALSKO females have reduced osteocalcin compared with female controls.