Table 3.

Distal Metaphyseal Trabecular Bone Traits for Male and Female Control and ALSKO Mice at 4, 8, and 16 Weeks of Age

	Age (weeks)	Male ALSKO	n	Male Control	n	Female ALSKO	n	Female Control	n
BV/TV (%)	4	11.1 ± 1 .8	8	10.2 ± 2.5	12	12.3 ± 2.0*	12	9.3 ± 1.3	11
	8	16.6 ± 2.6	6	17.2 ± 4.1	6	14.3 ± 1.2	5	11.6 ± 1.7	6
	16	14.0 ± 0.5	7	15.2 ± 1 .7	9	11.0 ± 1.7	9	10.9 ± 2.4	7
Tb.N	4	4.4 ± 0.6	8	4.4 ± 1.7	12	5.2 ± 1.5	12	3.7 ± 0.8	11
	8	5.6 ± 0.8	6	5.3 ± 0.6	6	5.5 ± 0.5*	5	4.2 ± 0.6	6
	16	5.2 ± 0.5	7	4.7 ± 0.5	9	5.1 ± 1.1	9	4.9 ± 1.1	7
Tb.Th (mm)	4	0.025 ± 0.001	8	0.024 ± 0.003	12	0.024 ± 0.003	12	0.025 ± 0.002	11
	8	0.030 ± 0.003	6	0.032 ± 0.004	6	0.026 ± 0.002	5	0.028 ± 0.001	6
	16	0.027 ± 0.002*	7	0.032 ± 0.003	9	0.022 ± 0.002	9	0.022 ± 0.001	7
Tb.Sp (mm−1)	4	0.21 ± 0.03	8	0.22 ± 0.07	12	0.18 ± 0.05*	12	0.25 ± 0.05	11
	8	0.1 5 ± 0.03	6	0.16 ± 0.03	6	0.16 ± 0.01*	5	0.22 ± 0.03	6
	16	0.17 ± 0.02	7	0.1 8 ± 0.02	9	0.18 ± 0.04	9	0.19 ± 0.05	7
TMD (mg/cc)	4	413 ± 34	8	439 ± 80	12	392 ± 67	12	445 ± 47	11
	8	599 ± 50	6	671 ± 94	6	504 ± 38	5	564 ± 47	6
	16	683 ± 69	7	778 ± 80	9	560 ± 93	9	542 ± 57	7

Mean values ± SD are presented.

^*Statistically different from control animals of the same sex and age (ANOVA, p < .05).