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. Author manuscript; available in PMC: 2012 Jan 5.
Published in final edited form as: Mol Psychiatry. 2010 Nov 16;17(1):62–70. doi: 10.1038/mp.2010.115

Fig. 4.

Fig. 4

Advanced paternal age confers autism susceptibility and also is a risk factor for other neurodevelopmental disorders. To combine Tsc2 haploinsufficiency with advanced paternal age in mice, we bred old Tsc2+/− males with WT females and generated controls by crossing young Tsc2+/− males with WT females and assessed social behavior in the adult offspring. Tsc2+/− and WT offspring of both young and old fathers showed normal social approach behavior. Plotted is the time (s) test subjects spent exploring either a cage containing a conspecific (social cage) or an empty cage. * P < 0.05, ** P > 0.01. Data represent means +/− S.E.M.