Table 2.

The influence of various cytokine on FMDV DNA vaccine

Cytokine	Effective on FMDV DNA vaccine
IL-1/IL-2	Advanced the humoral immune response induced by FMD inactivated vaccines. [38,39]
IL-6	Advanced the cellular immune response induced by FMD DNA vaccines, Promoting the maturation and immune function of dendritic cells [40]
IL-9	Increased a robust antigen specific cytotoxicity T lymphocyte response [41]
IL-15	Enhanced the cellular and mucosal immune response and the level of IFN-γinduced by FMD DNA vaccines [42]
IL-18	Increased the immunogenicity of DNA vaccines coding P12A and 3C of FMDV [43]
CSF	Enhanced immune responses against a plasmid DNA vaccine encoding FMDV empty capid [44]
INF-α/β	Advanced the cellular immune response induced by FMD DNA vaccines, Promoted the maturation and immune function of dendritic cells
INF-γ	Enhanced both humoral and cell-mediated immune responses[12]