A: Body weight of high-fat exposed RYGB (black circles, n = 5) and sham-operated (open circles, n = 6), as well as chow-fed control rats (open triangles, n = 6). B: Body composition as assessed by whole body magnetic resonance relaxometry (NMR), showing fat and lean mass before and after 14 weeks exposure to high-fat diet (left two bars), and for RYGB rats (dark gray bars), sham-operated (obese) rats (light gray bars), and non-operated, age-matched, chow-fed lean rats (white bars). C: Fasting plasma leptin levels at 3 months after surgery. Bars that do not share a common letter are significantly different from each other (P < 0.05; based on ANOVA followed by Fisher’s LSD posthoc test).