Table 2.
Histomorphological analysis of tumors from in vivo growth assay (n=3 mice; no usable tissue was retrieved from the 4th mouse). Each row represents an analysis of 2 tumors (PC3/FYN- or PC3/Ctrl as indicated). Tumors were scored for number of mitoses, amount of necrosis (by volume), number of intratumoral lymphoid aggregates, amount of spindle morphology (i.e. high grade appearance), and neovessel formation (requiring both CD31 staining and luminal formation by pathologist’s review).
| Mitoses (per 10 HPF) | Tumor necrosis | Lymphoid aggregates (per 10 hpf) | Epithelioid-Spindled cells | Neovessels (# per 10 HPF) | ||
|---|---|---|---|---|---|---|
| PC3/FYN- | 3170 R | 42 | <3% | <1 | 95:5 | 25 |
| 3172 R | 38 | 0% | 0 | 90:10 | 32 | |
| 3174 R | 46 | 2% | 0 | 80:20 | 29 | |
|
| ||||||
| PC3/Ctrl | 3170 L | 56 | 10% | 2 | 95:5 | 19 |
| 3172 L | 48 | 10% | 1 | 90:10 | 25 | |
| 3174 L | 51 | 6% | 0 | 85:15 | 19 | |