Table 2.
The Most Represented Gene Ontology (GO) Categories in Severe Endometriosis
| GO Biological Process | GO Cellular Component | GO Molecular Function |
|---|---|---|
| PE vs mild endometriosis PE | ||
| Transcription | Nucleus | Nucleotide binding |
| Transport | Intracellular | Protein binding |
| Cell adhesion | Cytoplasm | DNA binding |
| Nuclear mRNA splicing, via spliceosome | Extracellular region | Receptor activity |
| Proteolysis | Membrane | Nucleic acid binding |
| Translation | Mitochondrion | Catalytic activity |
| Signal transduction | Plasma membrane | Actin binding |
| Negative regulation of transcription from RNA polymerase II promoter | Membrane fraction | Binding |
| Lipid metabolic process | Integral to plasma membrane | Structural constituent of ribosome |
| Protein folding | Golgi membrane | Signal transducer activity |
| Regulation of transcription, DNA-dependent | Endoplasmic reticulum | Structural molecule activity |
| Skeletal system development | Integral to membrane | Zinc ion binding |
| Mesoderm formation | Golgi apparatus | Magnesium ion binding |
| Cell cycle | Ruffle | Receptor binding |
| Protein amino acid phosphorylation | Cytosol | Insulin receptor binding |
| Ubiquitin-dependent protein catabolic process | Cytoskeleton | RNA binding |
| Carbohydrate metabolic process | Extracellular space | Transporter activity |
| Mitochondrial electron transport, NADH to ubiquinone | Filopodium | NADH dehydrogenase activity |
| Multicellular organismal development | Mitochondrial inner membrane | Hydrolase activity |
| RNA processing | Eukaryotic translation initiation factor 4F complex | Ion channel activity |
| mRNA processing | Nucleolus | Calcium ion binding |
| Organ morphogenesis | Cornified envelope | Metalloendopeptidase activity |
| Cell fate determination | Endosome | Transcription factor activity |
| Angiogenesis | Inner acrosomal membrane | Ubiquitin-protein ligase activity |
| DNA repair | Microfibril | Iron ion binding |
| ESE vs mild endometriosis ESE | ||
| Transport | Nucleus | Protein binding |
| Transcription | Extracellular region | Nucleotide binding |
| Cell adhesion | Cytoplasm | DNA binding |
| Proteolysis | Membrane | Nucleic acid binding |
| Cell cycle | Intracellular | Catalytic activity |
| Signal transduction | Mitochondrion | Receptor activity |
| Translation | Plasma membrane | Actin binding |
| Lipid metabolic process | Membrane fraction | Signal transducer activity |
| Skeletal system development | Endoplasmic reticulum | Structural molecule activity |
| Immune response | Golgi membrane | Transporter activity |
| Nuclear mRNA splicing, via spliceosome | Integral to plasma membrane | Calcium ion binding |
| Carbohydrate metabolic process | Lysosome | Cytokine activity |
| Apoptosis | Extracellular space | RNA binding |
| Ubiquitin-dependent protein catabolic process | Cytosol | Ion channel activity |
| Protein amino acid phosphorylation | Golgi apparatus | Magnesium ion binding |
| Metabolic process | Soluble fraction | Binding |
| Protein folding | Ubiquitin ligase complex | Structural constituent of ribosome |
| Protein modification process | Nucleosome | Zinc ion binding |
| Regulation of cell growth | Endosome | Receptor binding |
| rRNA processing | Chromatin | Hydrolase activity |
| tRNA processing | Ruffle | Endopeptidase inhibitor activity |
| Ossification | Mediator complex | Metalloendopeptidase activity |
| DNA repair | Cytoskeleton | Ubiquitin-protein ligase activity |
| Acute-phase response | Integral to membrane of membrane fraction | Phosphoprotein phosphatase activity |
| Regulation of transcription, DNA-dependent | Exosome (RNase complex) | Antigen binding |
| MSE vs mild endometriosis MSE | ||
| Transcription | Nucleus | Nucleotide binding |
| Transport | Cytoplasm | Protein binding |
| Signal transduction | Extracellular region | DNA binding |
| Cell adhesion | Intracellular | Nucleic acid binding |
| Translation | Membrane | Receptor activity |
| Nuclear mRNA splicing, via spliceosome | Mitochondrion | Catalytic activity |
| Proteolysis | Plasma membrane | Signal transducer activity |
| Lipid metabolic process | Endoplasmic reticulum | Binding |
| Protein amino acid phosphorylation | Membrane fraction | Actin binding |
| Ubiquitin-dependent protein catabolic process | Golgi membrane | Transporter activity |
| Negative regulation of transcription from RNA polymerase II promoter | Integral to plasma membrane | RNA binding |
| Cell cycle | Lysosome | Calcium ion binding |
| Multicellular organismal development | Golgi apparatus | Structural molecule activity |
| DNA repair | Cytosol | Magnesium ion binding |
| Angiogenesis | Soluble fraction | Structural constituent of ribosome |
| Immune response | Integral to membrane | Zinc ion binding |
| Skeletal system development | Ubiquitin ligase complex | Ion channel activity |
| Protein folding | Proteasome complex | Ubiquitin-protein ligase activity |
| Apoptosis | Nucleosome | Iron ion binding |
| Carbohydrate metabolic process | Ruffle | Endopeptidase inhibitor activity |
| Metabolic process | Endosome | Phosphoprotein phosphatase activity |
| Regulation of cell growth | Chromatin | Receptor binding |
| Protein modification process | Telomeric region | Iron ion transmembrane transporter activity |
| Regulation of transcription, DNA-dependent | Mitochondrion | Enzyme inhibitor activity |
| mRNA processing | Coated pit | hydrolase activity |
Abbreviations: PE, proliferative endometrium; ESE, early secretory endometrium; MSE, mid-secretory endometrium.