Table 3.

Top Networks Regulated in Endometriuum from Severe Versus Mild Endometriosis

Top 5 networks regulated in proliferative phase endometrium (PE) from severe endometriosis versus mild PE
ID	Molecules in Network	Score	Focus Molecules	Top Functions
1	ADAMTS9, Caspase, CDKN2A, Cyclin A, DBP, E2f, EN2, ERCC1, FOXL2, GAS2L1, GNA11, GSPT1, GTF2H4, GTSE1, HNRNPA2B1, HNRNPH1, Ifn gamma, IFNGR1, IL32, KRT17, LIN37, MAFF, MAP3K7IP2, NFkB (complex), NLRP1, PYCARD, RBCK1, RRAS, RRM1 (includes EG:6240), SUZ12, TANK, TFDP1, TFIIH, UHMK1, WTAP	52	29	Cell Death, Hair and Skin Development and Function, Organ Development
2	ANXA1, BAX, C12ORF10, Calpain, CBLC, DDX3X, DNAJA1, EGFR, FANCA, Fibrinogen, GNRH, HSP, Hsp70, Hsp90, HSP90AA1, HSP90AB1, HSP90B1, HSPA8, HSPH1, IFN Beta, IL1, LAMB1, LARP1, LRRFIP1, MACF1, MYOF, PAFAH1B3, PCM1, PI3K, PLA2, Proteasome, REEP6, SFRP1, SSB, YWHAZ	39	24	Cellular Compromise, Post-Translational Modification, Protein Folding
3	14-3-3, ADD3, Akt, ASAH1, BAD, CCNL1, Cdc2, CEL, CP, Ctbp, CTBP1, Cyclin E, DCN, DDX42, EXOSC4, FZD2, GADD45GIP1, HISTONE, HMG20B, HNRNPR, JDP2, MAP2K1/2, NFIC, p70 S6k, PDGF BB, PDPK1, PNN, PP2A, RBM5, RBMX, RPL13, SF3A2, SF3B1, SFRS1, SFRS7	39	25	RNA Post-Transcriptional Modification, Lipid Metabolism, Small Molecule Biochemistry
4	ATP2B4, C1QTNF2, CTTN, DIO2, EPHA2, ERK, FAK, FBN1, Fgf, Fgfr, FGFR3, FOSL2, GDI2, IL27RA, ITGB1, JAK, JAK1, KLF13, LMO4, NRTN, NUFIP1, Pak, Pdgf, Pdgfr, PI3K p85, PLC gamma, PSMD7, PTPN11, RAB1A, Raf, RLIM, Shc, STAT, STAT5a/b, VCAN	32	21	Cellular Development, Skeletal and Muscular System Development and Function, Cellular Movement
5	ARAP1, BRD4, Calmodulin, Ck2, CRIM1, CSDC2, GGA1, Histone h3, Ikb, IKK (complex), Insulin, MATR3, MIR21 (includes EG:406991), MRPL12, MSX2, MTUS1, MYCN, NOP2, NUDT1, PIK3R1, PSPC1, PTEN, RBM14, RNA polymerase II, RPL13, SFPQ, SLC39A4, SMC4, SORD, UBE2G2, UBE2I, Ubiquitin, XIST, ZNF146, ZNF451	27	19	Cell Cycle, Embryonic Development, Cancer
Top 5 networks regulated in early secretory phase endometrium (ESE) from severe endometriosis versus mild ESE
ID	Molecules in Network	Score	Focus Molecules	Top Functions
1	ADAMTS9, AP1S1, BCR, BEX2, BGN, C1q, C1QA, C1QB, C1S, CARD10, Complement component 1, CXCL16, ENPP1, FMOD, G0S2, IgG, IGKC, IGL@, Igm, IL32, KRT7, KRT13, KRT17, NFkB (complex), NFKBIZ, PIGR, PTPLAD1, RBCK1, SERINC3, SERPING1, SLC16A1, SLC3A1, SLC7A1, STAP2, TNFRSF18	42	29	Skeletal and Muscular System Development and Function, Amino Acid Metabolism, Dermatological Diseases
2	ALP, ALPP, ASS1, CCNO, CFD, DDX3X, DIO2, DKK1, DNMT3A, Fgf, FGF18, FOXL2, FOXS1, Frizzled, FRZB, FXYD5, FZD2, FZD8, FZD10, GAS1, HES1, MAFF, MIB2, MSX2, MUC4, NEDD4L, P38 MAPK, PDGF BB, PORCN, SLC30A5, SMAD6, SOX4, TOB1, Wnt, WNT4	42	29	Cell Development, Connective Tissue Development and Function, Skeletal and Muscular System Development
3	ADD3, AGTRAP, ATP1A2, BMP7, C1QTNF2, CCL5, CTSG, ERK, Fibrin, FXYD4, Growth hormone, Igf, Igfbp, IGFBP3, IGFBP5, IGFBP6, IL27RA, LCN2, Mmp, MMP7, Na+,K+ -ATPase, NADPH oxidase, NAMPT, NRTN, POSTN, PRPF4, RARRES2, SERPINA1, SERPINA3, Smad2/3-Smad4, STRA13, Tgf beta, TIMP1, VCAN, VitaminD3-VDR-RXR	30	24	Cellular Movement, Cancer, Gastrointestinal Disease
4	ABP1, Adaptor protein 2, ADRB2, ALDOA, Angiotensin II receptor type 1, Beta Arrestin, C12ORF10, CAV1, Clathrin, CMTM8, Creatine Kinase, DAB2, Dynamin, EGFR, FBP1, GFER, HDL, HSP90AB1, HSPA8, MACF1, MAT2A, Mek, MIR21 (includes EG:406991), NCK, NFIB, NUMA1, PLTP, PTPRS (includes EG:5802), SNX9 (includes EG:51429), Sos, SPDEF, TRAK1, TRAK2, TRH, Vegf	30	24	Cellular Assembly and Organization, Cardiac Hypertrophy, Cardiovascular Disease
5	ADCYAP1R1, AGR2, BLVRB, Cbp/p300, CYP26A1, DHRS13, FJX1, FOXO1, hCG, Histone h3, Histone h4, HMOX1, HOXB8, KLF6, LBH, LSR, MAF, MGMT, MTUS1, Nfat (family), NPTX2, NPTXR, Oxidoreductase, PDGFA, Pkc(s), PURA, Rxr, SFRP4, SP3, TAGLN, TBL1X, Thyroid hormone receptor, TNFRSF4, TSPO, XIST	30	26	Developmental Disorder, Genetic Disorder, Neurological Disease
Top 5 networks regulated in mid-secretory phase endometrium (MSE) from severe endometriosis versus mild MSE
ID	Molecules in Network	Score	Focus Molecules	Top Functions
1	AHNAK, ARID5B, B3GNT1, BGN, CAND2, CHI3L1, COL16A1, COL6A2, EHD2, ELN, FOXS1, FXYD6, H1FX, HNRPDL, KCNG1, KRT7, MFAP2, MPHOSPH9, MYOF, NPTX2, NPTXR, PDLIM4, PDZK1IP1, PKIG, PLOD2, PMEPA1, RAB25, RAMP2, RBPMS, SCG5, SPAG4, STARD10, TGFB1, WFS1, ZNF581	51	35	Cancer, Cell-To-Cell Signaling and Interaction, Skeletal and Muscular Disorders
2	ANXA11, APBA3, APEX2, AQP1, BIK, C12ORF10, CBLC, CCT2, DOCK5, EFEMP2, EGFR, FAM107A, GAS5, GPC1, HNRNPH1, HSP90AB1, HSPH1, LDOC1, LRRFIP1, MACF1, MBNL1, MPG, PAFAH1B3, PGK1, PHLDA1, PSMD7, PTPRS (includes EG:5802), RAB1A, RABAC1, SCAMP1, SFRP1, TRAK2, TUBB2A, WWP1, ZNF638	51	35	Cardiovascular System Development and Function, Cellular Development, Cell Growth and Proliferation
3	BCLAF1, C19ORF43, CAMK2N1, CCNL2, CHD1 (includes EG:1105), CLK1, DDX42, DEAF1, ERAL1, ERK, GNRH, HMG20B, HNRNPA2B1, HNRNPL, IL27RA, IL6ST, KLF13, KLHL22, LMO4, LOXL1, PRPF4, RBM5, RBMX, RLIM, SEMA3F, SF3A2, SF3B1, SFRS1, SFRS5, SFRS7, SFRS11, SFRS2IP, TRA2A, UBXN1, WSX1-gp130	42	32	RNA Post-Transcriptional Modification, Cancer, Cellular Growth and Proliferation
4	3 BETA HSD, AKR7A2, CCNL1, CNN1, CRIM1, CSRP2, DDX5, DUSP1, GLIS2, HELZ, HOXB8, HSD3B7, MAT2A, MEIS1, MIR21 (includes EG:406991), NAMPT, NBL1, NKIRAS2, PDGF BB, RNA polymerase II, RPL13, SERPINA3, SLC1A1, SP2, TAGLN, TEAD2, TEAD4, TIA1, TNNC1, TOB1, UNC5B, XAB2, XDH, YAP1, ZNF83	42	32	Cellular Assembly and Organization, Drug Metabolism, Genetic Disorder
5	ABCG1, ADAMTS9, AEBP1, ATF5, CARD10, CLIP2, CRISP3 (includes EG:10321), CXCL16, DBP, GFER, HDL, HES1, HEY2, LCN2, NCOA7, NFkB (complex), NFKBIZ, Notch, NOTCH2, NOTCH3, PLTP, PRDX2, PYCARD, RBCK1, RIOK3, RTKN, RTN4R, S100P, Secretase gamma, SLC3A1, SLC7A1, TAX1BP3, TCEA2, WTAP, ZMYND11	40	31	Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry