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The effects of bilateral PVN infusion of NBI-27914 on neuronal activity in the PVN of rats with ischemia-induced HF. Fra-LI activity (black dots), an indicator of chronic neuronal excitation, increased in the PVN of HF rats when compared with SHAM rats. Fra-LI activity was lower in the NBI-27914-treated HF rats than in vehicle-treated HF rats. *P < 0.05 versus SHAM + NBI-27914 or SHAM + vehicle; †P < 0.05 HF + NBI-27914 versus HF + vehicle
