Table 1.

Echocardiographic measurements (n = 14)

	HF + NBI-27914	HF + vehicle	SHAM + NBI-27914	SHAM + vehicle
Measurements at baseline
LVEDV (ml)	0.72 ± 0.08*	0.71 ± 0.07*	0.36 ± 0.05	0.39 ± 0.05
LVEDV/Mass	1.05 ± 0.08*	1.08 ± 0.09*	0.54 ± 0.05	0.59 ± 0.06
LVEF	0.35 ± 0.04*	0.37 ± 0.05*	0.82 ± 0.05	0.84 ± 0.07
IZ (%)	48 ± 4	46 ± 4	–	–
Measurements at 4 weeks
LVEDV (ml)	1.35 ± 0.07*,‡	1.40 ± 0.08*,‡	0.32 ± 0.03	0.35 ± 0.04
LVEDV/Mass	1.61 ± 0.12*,‡	1.70 ± 0.15*,‡	0.56 ± 0.05	0.61 ± 0.06
LVEF	0.34 ± 0.03*,†	0.24 ± 0.03*,‡	0.83 ± 0.07	0.80 ± 0.06
IZ (%)	46 ± 4	50 ± 5	–	–

Values are mean ± SEM

SHAM sham-operated control, HF heart failure, LVEDV left ventricular end-diastolic volume, LVEF left ventricular ejection fraction, IZ% percent ischemic zone

^*P < 0.05 versus SHAM + NBI-27914 or SHAM + vehicle;

^†P < 0.05 HF + NBI-27914 versus HF + vehicle;

^‡P < 0.05, 4 weeks versus 24 h value