Figure 2. The backbone-dependent rotamer library problem.
ϕ-ψ scatter plot of nine leucine rotamers and statistics of the total number of rotamers of each type. The scatter plot has larger and brighter markers for rare rotamers and smaller and darker markers – for abundant rotamers. The total number of rotamers differs significantly among the 9 types. The relative distributions of each rotamer depend strongly on backbone conformation.