Table 5.

Univariate Analysis of Relationship Between H pylori Genotyping and Histology

		Antrum			Corpus
	n	H pylori density	Neutrophil infiltration	Atrophy	H pylori density	Neutrophil infiltration	Atrophy
Western countries
BabA
BabA-H	160	2.5 (2.7)	2.6 (2.5)	1.3 (0.8)	2.5 (2.7)	1.8 (1.9)	0.3 (0)
BabA-L	13	3.4 (3.5)	3.3 (3.0)	2.1 (2.0)	3.2 (3.3)	2.4 (2.0)	0.8 (0.5)
BabA negative	22	2.1 (2.3)	1.6 (1.4)	0.8 (0)	1.8 (2.0)	1.0 (0.8)	0.1 (0)
P value (L vs H)		<.001	.083	.002	<.001	.006	.004
P value (H vs negative)		NS	.053	.013	.029	.001	.004
P value (L vs negative)		<.001	.003	<.001	<.001	<.001	<.001
cagA
Positive	162	2.6 (2.8)	2.7 (2.5)	1.4 (1.0)	2.6 (2.8)	1.9 (2.0)	0.4 (0)
Negative	33	2.3 (2.5)	2.0 (2.3)	0.8 (0)	2.0 (2.0)	1.2 (0.9)	0.1 (0)
P value		NS	.043	.007	<.001	.006	.099
vacA
s1	164	2.6 (2.8)	2.7 (2.5)	1.3 (1.0)	2.6 (2.7)	1.9 (2.0)	0.3 (0)
s2	31	2.3 (2.5)	2.0 (2.4)	0.9 (0.5)	2.0 (2.0)	1.2 (1.0)	0.2 (0)
P value		NS	.034	.062	.004	.003	NS
East Asia
BabA
BabA-H	141	2.6 (2.5)	2.2 (2.0)	1.1 (1.0)	2.2 (2.0)	1.5 (1.5)	0.6 (0)
BabA-L	15	3.3 (3.0)	3.1 (3.0)	2.0 (2.0)	2.8 (3.0)	2.1 (2.0)	1.1 (1.0)
P value		.011	.008	.015	.029	NS	.091
cagA
Positive	152	2.6 (3.0)	2.3 (2.0)	1.1 (1.0)	2.3 (2.0)	1.6 (1.5)	0.6 (1.0)
Negative	4	2.0 (1.5)	1.8 (1.5)	1.8 (2.0)	2.3 (1.5)	1.4 (1.8)	1.8 (0.5)
P value		NS	NS	NS	NS	NS	NS

NOTE. Analyses were performed by Mann–Whitney rank sum test (cagA status/vacA s genotypes) and Kruskal-Wallis test with Scheffe test (BabA types). Nine samples (5 from Western countries and 4 from East Asia) had borderline BabA status and were excluded. Twenty samples from Korea also were not included because the number of biopsy specimens was ≤2. For NS, P > .10. Data for vacA s region in Japan were not presented because all strains studied were vacA s1 genotype. For histologic scores (minimum 0, maximum 5), the means (median) are presented.