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NMDA antagonist and VGCC blocker prevented induction of CRF-induced LTP in saline-treated and cocaine-withdrawn groups. Slices were obtained 14 days after the last saline or cocaine injection. Traces above show fEPSPs recorded at the time points indicated by the respective numbers on the graphs. APV (50 μM, A, B) and nimodipine (10 μM, C, D) blocked CRF-induced LTP in both animal groups.
