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. Author manuscript; available in PMC: 2011 Jun 20.
Published in final edited form as: Eur J Neurosci. 2010 Mar 8;31(6):1027–1042. doi: 10.1111/j.1460-9568.2010.07148.x

Figure 6.

Figure 6

The enhanced CRF-induced LTP recorded in the cocaine-withdrawn group was dependent on the extent of GABAergic inhibition. (A) Concentration-response relationship for PTX in the saline-treated group showed the greatest potentiation in CRF-induced LTP at 10 μM (filled circles). (B) The enhanced CRF-induced LTP in the cocaine-withdrawn group occurred at 10 (filled triangles) and 50 μM PTX (inverted triangles). (C) Comparing CRF-induced LTP with GABAergic intact (no PTX) in slices showed no difference in CRF-induced LTP in the two treatment groups suggesting removal of inhibition was necessary for the enhanced potentiation after cocaine withdrawal. (D) At 50 μM PTX, an enhanced CRF-induced LTP was recorded in the cocaine withdrawal group (inverted triangle). (E) LTP differences between cocaine-withdrawn and saline-treated groups were measured at 10 μM and 50 μM PTX but not with GABAergic inhibition intact (no PTX).