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. Author manuscript; available in PMC: 2011 Jun 20.
Published in final edited form as: J Mol Neurosci. 2008 Aug 2;38(2):152–158. doi: 10.1007/s12031-008-9136-9

Figure 3.

Figure 3

NRIF regulates transcription of Hmgcr and Dhcr7, the first and last enzymes in cholesterol biosynthesis pathway. Neuro2a cells were transfected with either NRIF shRNA or non-silencing shRNA and stable cell lines were established using puromycin selection. qPCR analysis shows that in addition to NRIF down regulation, both Hmgcr and Dhcr7 transcripts were significantly down regulated (-ΔΔCt=−0.48, p<0.01 and -ΔΔCt=−0.68, p<0.01, respectively)