Figure 1.

Experience and MD-enabled visual plasticity from eye-opening. (A) The experience of measuring OKT through both eyes from P15 (green circles) leads to binocular enhancement of OKT SF thresholds (~ 60%, right eye responses plotted) that plateau at P25, relative to responses in naive adults (black arrow), or with testing from P25 (blue squares; Baseline; replication of Prusky et al., 2008). (B) P15–P25 MD with OKT experience led to enhancement through the non-deprived eye (NDE; purple trace) comparable to that with binocular experience (green dashed line from Figure 1A). Upon opening the deprived eye (DE; orange trace), however, thresholds through both eyes fell to ~0.2 c/deg (~60% reduction). (C) P15–P25 MD without OKT experience did not differ from baseline (orange, purple, and blue traces from Figure 1B). (D) P15–P19 MD with OKT experience was also sufficient to generate loss-of-function through both eyes. SEMs are plotted on this and other panels, but are often occluded by symbols.