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. Author manuscript; available in PMC: 2011 Jun 20.
Published in final edited form as: Chemistry. 2009 Nov 2;15(43):11723–11729. doi: 10.1002/chem.200900643

Table 3.

Conversion of LY294002 by different P450 BM3 variants into the most abundant metabolites produced by rat liver microsomes.

graphic file with name nihms-297808-t0003.jpg
Variantb % Conversion 18 19 20
1 9-10A L75I 10 50
2 9-10A A78S 7 71
3 9-10A F87V 6 100
4 9-10A T260S 11 9
5 68-8F 9 11
a

>1% abundance following in vitro reaction of LY294002 with rat liver microsomes.

b

variants in normal type were selected for activity on alkanes.[18, 19]