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. Author manuscript; available in PMC: 2011 Jun 20.
Published in final edited form as: Curr Opin Neurobiol. 2010 Jan 7;20(1):92–99. doi: 10.1016/j.conb.2009.12.004

Figure 1. The structure of the APC.

Figure 1

The APC is composed of at least 12 core subunits including the Cul1-related scaffold protein APC2 and the RING finger protein APC11 shown in red. The APC associates with one of two co-activators, Cdh1 or Cdc20 (shown in yellow), which confer substrate specificity and stimulate the ubiquitin ligase activity of the APC. The tetratricopeptide repeat (TPR) containing core subunits Cdc27, Cdc23, and Cdc16 (shown in blue) act as a scaffold to promote the interaction of Cdh1 and Cdc20 with the APC.