Table 2.
Nonpolymorphic antigens in B-cell malignancies.
| Antigen class | Example | Tumor expression | Ref. |
|---|---|---|---|
| Immunoglobulin idiotype | CDR region of Id | Individual Id expressed in each B-cell malignancy | [51] |
| Viral antigens | EBV latent proteins (e.g., EBNA-1, 3, LMP-1,2) | EBV-LPD, Hodgkin disease | [65,68] |
| Chromosome translocation | Bcr/abl | Philadelphia chromosome-positive B-ALL | [42] |
| Overexpressed proteins | Bcl-2 | B-CLL | [149] |
| Fibromodulin | B-CLL | [74] | |
| Mdm2 | B-CLL | [73] | |
| RHAMM/CD168 | B-CLL | [150] | |
| Survivin | B-CLL | [75] | |
| DKK1 | MM | [78] | |
| HM1.24 | MM | [77] | |
| PRAME | MM, B-CLL | [150] | |
| SPAN-XB | MM | [76] | |
| WT-1 | MM, B-ALL | [80,81] | |
| Aberrantly expressed proteins | Cancer-testes antigens (e.g., NY-ESO-1, LAGE, MAGE) | MM | [80] |
B-ALL: B-cell acute lymphoblastic leukemia; B-CLL: B-cell chronic lymphocytic leukemia; CDR: Complementarity determining region; EBV: Epstein–Barr virus; Id: Idiotype; LPD: Lymphoproliferative disease; MM: Multiple myeloma.