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. Author manuscript; available in PMC: 2012 May 27.
Published in final edited form as: Chemistry. 2011 Apr 27;17(23):6326–6329. doi: 10.1002/chem.201100444

Scheme 6.

Scheme 6

Alkylative cyclization of an enoate / chiral allene. (a) ZnCl2, MeLi, Ti(O-iPr)4, Ni(COD)2 (20 mol %), -20 °C to rt, 77 % (in the case of 23a), 24 % (in the case of 23b); (b) MeOMgBr, toluene/THF, 0 °C to rt, 75 % (in the case of 24a), 79 % (in the case of 24b).