Figure 3. Akt1 and Akt2 predominantly affected PMA proliferation.
Growth of p53cKO;EGFRvIII PMAs was measured in Pten wildtype (WT) or deficient (cKO) cells that were (A) Akt1 WT or KO (B) Akt1 WT expressing Akt2-specific shRNA, or Akt1 KO expressing (C) Akt2-specific or (D) Akt3-specific shRNA. Plotted are the mean cumulative population doublings ± SEM. n= number of individual cultures per group.