Table 1.
Frequency of lymphoma, myeloproliferation and other malignancies
Lymphoma | Myelopro- liferation | Other Malignancies* | Myeloid Hyperplasia | ||
---|---|---|---|---|---|
1 | WT Control | 0/20(0) | 0/20(0) | 0/20(0) | 0/20(0) |
2 | NQO2-Null Control | 5/20(25) | 0/20(0) | 0/20(0) | 18/20(90) |
3 | P<0.0281 | P<0.9999 | P<0.9999 | P<0.0001 | |
4 | WT 1Gy | 0/20(0) | 0/20(0) | 0/20(0) | 0/20(0) |
5 | NQO2-Null 1Gy | 8/19(42) | 5/19(26) | 6/19(32) | 19/20(95) |
6 | P<0.0002 | P<0.0001 | P<0.0001 | P<0.0001 | |
7 | WT 3Gy | 2/19(11) | 0/19(0) | 0/19(0) | 0/20(0) |
8 | NQO2-Null 3Gy | 13/18(72) | 4/18(22) | 3/18(17) | 18/20(90) |
9 | P<0.0001 | P<0.0001 | P<0.0205 | P<0.0001 |
Most other malignancies were lung adenocarcinoma.
Numbers in parenthesis show the percentage of mice with lymphoma, myeloproliferation, other malignancies, and myeloid hyperplasia.
The experiments were setup in four groups and each group contained 5 animals. P values for WT and NQO2-Null control are shown in line 3. P values for WT 1Gy versus NQO2-Null 1Gy are shown in line 6. P values for WT 3Gy versus NQO2-Null are shown in line 9.