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. 2011 Mar 22;300(6):E1135–E1145. doi: 10.1152/ajpendo.00001.2011

Fig. 5.

Fig. 5.

Silencing MnSOD abolishes improved diabetic EPC functions induced by AMPK activation. A: MnSOD siRNA transfection before AICAR treatment reduced MnSOD protein level by 60% vs. scramble control transfection in diabetic EPCs; n = 5, *P < 0.05 vs. STZ and STZ + MnSOD siRNA + AICAR. B: silencing MnSOD abolished improved tube formation caused by AICAR treatment (1 mM for 24 h) in diabetic EPCs. Photomicrographs are representative of 5 independent experiments; n = 5. *P < 0.05 vs. STZ and STZ + MnSODsiRNA + AICAR. C: increased adhesion by AICAR was not significantly affected by silencing MnSOD; n = 4–5. *P < 0.05 vs. STZ. D: improved migration of diabetic EPCs was reversed by MnSOD siRNA pretreatment; n = 4–5. *P < 0.05 vs. STZ and STZ + MnSOD siRNA + AICAR.