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. Author manuscript; available in PMC: 2011 Jun 20.
Published in final edited form as: Comp Biochem Physiol C Toxicol Pharmacol. 2009 Jun 16;150(3):383–389. doi: 10.1016/j.cbpc.2009.06.003

Figure 5.

Figure 5

Fold change of the HIF reporter vector activity in PLHC-1 cells exposed to 500, 1000, or 1500 nM BaP and co-transfected with (A) 0, (B) 0.25, (C) 0.5 and (D) 1.0 μg of the ARNT expression vector. Over expression of ARNT failed to eliminate the effects of BaP on HIF reporter activity (ARNT*hypoxia*BaP interaction p>0.05; BaP main effect for HIF reporter p<0.001; BaP main effect for HIF reporter/0.025ARNT p<0.001; BaP main effect for HIF reporter/0.5ARNT p<0.001; BaP main effect for HIF reporter/1.0ARNT p<0.001). Bars are means normalized to normoxia DMSO ± SE, n (replicate wells) = 12-14.