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A network of genes essential for ganglion cell development. Edges in this graph are based on evidence that Pax6 actives Math5 expression163 and Math5 suppresses Math3 and NeuroD to promote ganglion cell fate.82,84 In addition, Math5 promotes Brn3b and Isletl expression,64,87,88 which in turn positively regulate genes like Eomes,92 Shh164 and Barhl2.59 Brn3b is also activated by Wt1.94 Blue edges between genes indicate activation, while red edges indicate repression.
