Figure 8.
A network of genes essential for rod and cone photoreceptor cell development.
The edges in this graph are based on evidence that Otx2 activates Crx12 while Ataxin-7118 and BAF119 repress Crx transactivation. Crx and Nrl synergically activate the rod specific pigment rhodopsin,114 while Crx promotes expression of M and S cone-specific opsins.115,116 Nr2e3, which is activated by Nrl represses expression of both S- and M-opsin.127 NeuroD is necessary for sustained expression of TRβ2,113 which inhibits S-opsin and activates M-opsin expression.142 RXRα146 promotes cone-specific gene expression while RXRγ145 represses S-opsin expression. Blue edges between genes indicate activation, while red edges indicate repression.