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A–C: hypercapnia (8% CO2) produced a rise in FR (A), reduction in Rm (B), and depolarization (C). D: summary of the augmentation of neuronal FR by hypercapnia with and without changing extracellular pH (pHo). Two-tailed paired Student's t-test was used for the comparison of each group. All of these changes were statistically significant (**P < 0.01; ***P < 0.001). No significant differences were found between groups with 1-tailed Student's t-test (2-sample assuming equal variances).
