Figure 3.
Dystrophic gene expression fingerprint in Nf1Prx1 mice. (A) Transcriptional fingerprint of the Nf1 muscle fibrosis. Upregulated are genes encoding extracellular matrix proteins, proteins regulating actin cytoskeleton, transcription factors involved in cancer process, receptors and signal conveying molecules involved in the regulation of MAPK, IP3 and cAMP-signaling pathways. P-values were determined with one-way ANOVA analysis. (B) Analysis of the microarray expression profile of the adult Nf1Prx1 mice triceps muscles (see Materials and Methods for KEGG class enrichment analysis). Among 1379 genes which were found upregulated in mutant muscle, six functional KEGG classes are significantly overrepresented in the data set (lower panel). (C) Overlap between gene sets deregulated in Nf1Prx1 muscles, and a gene set deregulated in muscle of mice carrying a mutation in the dystrophin gene (Mdx) (18).