Figure 3.

Progressive motor dysfunction on the rotarod task. NTg (black square) and N586-82Q-C63 (C63, grey diamond) mice were assessed by rotarod at 3 (3 m/o), 6 (6m/o) and 8 (8 m/o) months of age. For comparison, 8 m/o mice transgenic for N586-23Q (line A2) were tested (light grey circles). At each age tested, N586-82Q-C63 mice were statistically different from non-transgenic littermates (P < 0.05, n = 6–8 for each group). In contrast, the performance of N586-23Q-A2 mice was not different from NTg mice.