Table 2.

Sequential multi-locus regression analysis identified three independent, prostate cancer susceptibility SNPs in 11q13

SNP	Per allele odds ratio (95% CI)	P-value
rs10896449	1.14 (1.09–1.20)	8.69 × 10−9
rs12793759	1.11 (1.04–1.18)	1.41 × 10−3
rs10896438	1.07 (1.02–1.12)	5.92 × 10−3

A three-SNP model conditioned on the original CGEMS hit rs10896449 and the novel second signal rs12793759 was used to assess whether a third independent signal was among the remaining SNPs. The most significant SNP in that analysis was rs10896438, which is in strong LD with a marker previously reported (20); it achieved borderline significance after permutation-based adjustment for multiple testing (adjusted P = 0.054). Reported P-values are unadjusted.