Table 1.

Novel loci with single SNP significance of P < 5.0 × 10⁻⁷ for association with glioma on 7p11.2

	Study	Case genotypes			Control genotypes			Case MAF	Control MAF	OR (95% CI)*	P-value	Population-corrected P-value
		Common homozygotes	Heterozygotes	Rare homozygotes	Common homozygotes	Heterozygotes	Rare homozygotes
rs11979158; 55 126 843 bp; minor allele = G; risk allele = A	France	1091	310	22	858	313	18	0.124	0.147	1.22 (1.03–1.43)	0.017	6.40 × 10−3
	Germany	635	193	17	893	371	46	0.134	0.177	1.36 (1.16–1.64)	2.70 × 10−4	7.75 × 10−3
	UK	471	142	18	1836	776	85	0.141	0.175	1.28 (1.09–1.54)	3.75 × 10−3	2.75 × 10−3
	USA	908	312	27	1564	601	71	0.147	0.166	1.15 (1.01–1.32)	0.036	0.031
	Combined									1.23 (1.15–1.35)	7.03 × 10−8	7.72 × 10−8
rs2252586; 54 946 418 bp; minor allele = T; risk allele = T	France	601	636	185	580	496	114	0.354	0.304	1.25 (1.11–1.41)	1.84 × 10−4	7.09 × 10−5
	Germany	366	374	106	652	536	120	0.346	0.297	1.25 (1.10–1.43)	7.24 × 10−4	8.05 × 10−4
	UK	285	278	68	1335	1131	232	0.328	0.296	1.16 (1.02–1.33)	0.024	0.020
	USA	580	551	116	1091	962	183	0.314	0.297	1.09 (0.97–1.20)	0.133	0.103
	Combined									1.18 (1.11–1.25)	7.89 × 10−8	2.09 × 10−8

*ORs and 95% CI per copy of the risk allele.