FIGURE 1.

METH preconditioning induces differential striatal transcriptional responses to large doses METH. The Venn diagram shows the overlap of genes identified by the three sets of comparisons. The animals were injected and euthanized as described in the text. RNA was extracted from rat striatal tissues. The microarray experiments were performed as described in the method section. Genes were identified as significantly changed if they show greater than ±1.7-fold changes at p < 0.025.