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. 2010 Jul 2;9(2):165–181. doi: 10.2203/dose-response.10-011.Cadet

FIGURE 3.

FIGURE 3

Effects of large doses of METH on striatal Hmox-1, Hmox-2, Nrf2, and DnaJc3 mRNA levels. Data were obtained using RNA isolated from 5–6 animals per group and measured individually. The mRNA levels were normalized to 18S rRNA levels. The values are means ± SEM in comparison to the SS group. METH caused substantial increases in (A) Hmox-1 in the SM group but not in (B) Hmox-2. There were also METH-induced increases in the expression of (C) Nrf2 in the SM group and of (D) DnaJc3 in both the SM and MM groups. Keys to statistics: *, **, *** p < 0.05, 0.01, 0.001, respectively, in comparison to the SS group; #, ### p < 0.05, 0.001, respectively, in comparison to the MS group; !!, !!!, p < 0.001, respectively, in comparison to the SM group.