Table 1. Five most bioactive compounds from cluster 2.
ID ChemBridge | IC50 Cell Degranulation (µM) | Kd (µM) | Solubility (µM) | Lipinski Violations |
6197026 (C-13) | 2 | 4 | ND | 1 (log P) |
6282824 | 5 | 5.6 | 4.5 | 0 |
7495334 | 10 | 1.6 | 35.2 | 0 |
7501888 | 4 | 8.2 | 6 | 2 (log P, MW) |
7752193 | 10 | 8 | 0.3 | 0 |
7783660 | 10 | 4.8 | 12.9 | 1 (MW) |
Compound C-13 is included as a reference.