Table V.

Baseline and follow-up laboratory data for the 15 healthy Vietnamese male volunteers in this 4-sequence crossover artemisinin study. All parameters are presented as mean values (SD) [range].

Variable	Pretreatment	Posttreatment	P
Biochemistry
Urea, mM	3.49 (0.91) [2.4–5.2)	5.36 (1.5) [2.4–7.2]	0.001⁎
Glucose, mM	4.46 (0.68) [3.5–6.5]	3.91 (0.35) [3.5–4.4]	0.002⁎
Creatinine, μM	72.5 (8.9) [54–92]	92.7 (16) [73–115]	0.001⁎
Total bilirubin, μM	9.53 (2.7) [5.0–13]	16.1 (4.0) [9.0–20]	0.001⁎
Total protein, g/L	71.3 (2.1) [68–74]	77.3 (5.1) [67–82]	0.001⁎
Albumin, g/L	39.7 (1.8) [36–42]	39.7 (4.2) [30–46]	0.930
Globulin, g/L	31.5 (2.3) [28–36]	37.7 (6.5) [30–47]	0.002⁎
Albumin/globulin ratio	1.25 (0.14) [1.0–1.5]	1.08 (0.19) [0.80–1.4]	0.003⁎
Ferritin, μg/L	126 (57) [55–280]	117 (36) [69–190]	0.520
Magnesium, mM	1.09 (0.20) [0.80–1.5]	0.896 (0.17) [0.70–1.1]	0.001⁎
AST, U/L	20.5 (8.70 [11–36]	29.1 (16) [19–80]	0.001⁎
ALT, U/L	35.3 (18) [11–68]	44.7 (25) [15–120]	0.190
Hematology
Hematocrit, %	46.8 (2.8) [43–54]	47.7 (2.5) [45–53]	0.680
Hemoglobin, g/dL	15.6 (0.85) [14–18]	15.6 (0.78) [15–18]	0.770
Erythrocytes, 1012/L	5.33 (0.51) [4.8–6.1]	5.23 (0.49) [4.6–6.1]	0.100
Reticulocytes, %	0.653 (0.58) [0.10–2.5]	0.700 (0.34) [0.10–1.5]	0.520
Thrombocytes, 109/L	252 (51) [150–320]	258 (59) [130–330]	0.360
Leukocytes, 109/L	8.49 (1.7) [5.9–12]	7.62 (1.5) [5.4–10]	0.015⁎
Neutrophils, %	56.4 (7.1) [47–70]	53.7 (6.5) [45–63]	0.120
Eosinophils, %	5.15 (5.3) [0.87–21]	5.34 (3.2) [1.6–13]	0.110
Basophils, %	0.808 (0.33) [0.24–1.4]	1.12 (0.49) [0.23–2.1]	0.018⁎
Monocytes, %	6.96 (1.4) [5.2–11]	7.47 (1.4) [5.3–10]	0.210
Lymphocytes, %	30.6 (6.3) [19–38]	32.5 (6.2) [21–43]	0.041⁎

AST = aspartate aminotransferase; ALT = alanine aminotransferase.

^⁎Significant difference at P < 0.05 between pretreatment and posttreatment values using a Wilcoxon signed rank test.