Figure 6-4257.

Electron microscopy of S+lcat−/− kidneys. A: Six-month-old S+lcat−/− kidneys show numerous mesangial (arrow) and glomerular endothelial (arrowheads) osmiophilic inclusions. There is mild mesangial matrix expansion. B: At 10 months of age, S+lcat−/− kidneys show fewer mesangial osmiophilic deposits (single arrow) compared to 6-month mice. However there is evidence of mesangial injury in the form of mesangial hyalinotic lesions (double arrows). Podocytes show osmiophilic inclusions (arrowhead) associated with focal foot-process effacement. C: Ten-month-old S+lcat−/− mice show foci with several osmiophilic inclusions in podocytes (arrows) with only minor localized foot process effacement. Osmiophilic inclusions are present in glomerular endothelial cells (arrowhead). D: Ten-month-old S+lcat−/− mice show tubulointerstitial electron-dense inclusions. Osmiophilic inclusions are present in proximal tubular epithelial cells (arrowhead), adjacent to tubular basement membranes (double arrow), and scattered through the interstitium. Occasional interstitial foam cells (single arrow) contain osmiophilic dense inclusions. (PCT, proximal convoluted tubular epithelial cell). Original magnification, ×3000 (A), ×2500 (B), ×8000 (C), and ×2500 (D).