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. 2011 Feb 16;4(4):456–467. doi: 10.1038/mi.2011.6

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Copyright © 2011 Society for Mucosal Immunology

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Mean nontypeable Haemophilus influenzae (NTHI) biomass scores for each bulla after transcutaneous immunization (TCI) following a therapeutic regimen, based on blinded evaluation and ranked on a 0 to 4+ scale of relative residual biomass. *Statistically significant compared with receipt of dmLT alone (P<0.05). Receipt of LB1, rsPilA, or chimV4, admixed with dmLT, resulted in significantly enhanced resolution of NTHI biofilms established within the middle ear space. dmLT, double mutant of E. coli heat-labile enterotoxin; rsPilA, recombinant soluble PilA.