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Schematic representation of the different subpopulation of striatal A2ARs. Presynaptic A2ARs are localized in glutamatergic terminals that contact the dynorphynergic medium spiny neuron (DYN-MSN), where they form heteromers with A1Rs. Postsynaptic A2ARs are localized in the enkephalinergic medium spiny neuron (ENK-MSN), where they from heteromers with D2Rs, CB1Rs, and mGlu5Rs. AC, adenylyl cyclase; EC, endocannabinoid; GLU, glutamate.
