Table 3.

Correlation of biomarkers with therapy response

Marker	Time	Response N = 32	No-Response N = 39	P-Value
Nucleosomes (ng/mL)	0 h	107.5	80.7	0.142
	24 h	81.8	231.1	0.002
	pc.	-26.2	114.3	< 0.001
AFP (ng/mL)	0 h	4.4	7.9	0.011
	24 h	4.2	7.9	0.010
	pc.	0	0	0.822
CYFRA 21-1 (ng/mL)	0 h	1.8	2.0	0.349
	24 h	2.0	2.2	0.101
	pc.	0	14.3	0.229
LDH (U/L)	0 h	198.5	200.0	0.288
	24 h	240.0	250.0	0.746
	pc.	21.6	21.0	0.712
CRP (mg/dL)	0 h	0.4	0.8	0.424
	24 h	1.2	1.5	0.361
	pc.	100.0	133.3	0.644
CHE (kU/L)	0 h	4.4	4.4	0.636
	24 h	4.6	4.4	0.652
	pc.	3.0	4.6	0.514
AST (U/L)	0 h	41.5	56.0	0.084
	24 h	101.0	89.0	0.556
	pc.	102.6	50.0	0.241
ALT (U/L)	0 h	37.5	38.0	0.652
	24 h	63.5	57.0	0.138
	pc.	72.6	19.8	0.051
GLDH (U/L)	0 h	5.0	7.7	0.150
	24 h	12.7	18.4	0.922
	pc.	151.7	90.0	0.280
Bilirubin (mg/dL)	0 h	0.9	1.0	0.276
	24 h	1.5	1.6	0.231
	pc.	47.7	60.0	0.995
GGT (U/L)	0 h	109.0	192.0	0.034
	24 h	108.5	206.0	0.027
	pc.	2.8	5.7	0.234
AP (U/L)	0 h	119.5	140.0	0.023
	24 h	112.5	143.0	0.006
	pc.	-4.1	1.9	0.317

Median values and p-values (Wilcoxon-test) are shown for the two response groups (pc. = percental changes)