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. 2011 May 18;6:25. doi: 10.1186/1745-6150-6-25

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Copyright ©2011 Alekseyenko et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Previously known SNP associations become statistically independent of the phenotype conditioned on 4 SNPs discovered by TIE*. The phenotypic response variable is shown with black circle in the middle ("RA") and SNPs are shown with white ovals. SNPs that have a univariate association with the phenotype (according to G²test at significance level α = 5%) have a path to "RA". SNPs that become statistically independent of the phenotype given a subset of 4 SNPs found by TIE* (so-called "conditioning set") are connected with "RA" by indirect paths that go through SNPs in the corresponding conditioning set.