Fig. 7.

Effect of persistent intracellular H. pylori on hepatocyte DNA fragmentation or DNA synthesis after five passages with removals of adherent bacteria. DNA fragmentation (a) and DNA synthesis (b) was assessed after five passages of Huh7 cells sub-cultured with or without intracellular H. pylori 11637 or 401C after removal of adherent H. pylori. Camptothecin or IL-6 was used instead of H. pylori as a positive control in the experiments of DNA fragmentation and DNA synthesis, respectively. Data are presented as mean ± SEM. **P < 0.01