TABLE 2.
Genital Tract Disorders and Associations with Heat-Stable HIF
| Variable | Present/Number Women Assessed (%) |
Unadjusted Association With Heat-Stable HIF OR (95% CI) |
Full Model: Association With Heat-Stable HIF OR (95% CI) |
Reduced Model: Association With Heat-Stable HIF OR (95% CI) |
|---|---|---|---|---|
| Bacterial vaginosis by Nugent criteria | ||||
| Normal flora (0–3) | 112/236 (47.5%) | 1.0 | 1.0 | 1.0 |
| Intermediate flora (4–6) | 34/236 (14.4%) | 19.64 (2.21, 174.94)† | 43.32 (3.60, 521.07)# | 26.00 (2.63, 256.80)†† |
| BV(7–10) | 90/236 (38.1%) | 100.64 (13.46, 752.47)‡ | 51.74 (5.04, 530.72)** | 78.00 (10.09, 602.91)‡‡ |
| Vaginal discharge | 186/297 (62.6%) | 2.74 (1.41, 5.32)§ | 4.94 (0.66, 36.91) | |
| Trichomonas by microscopy | 10/294 (3.4%) | 6.33 (1.73, 23.23)¶ | 0.20 (0.02, 2.53) | |
| Vaginal fluid pH >4.5 | 183/297 (61.6%) | 9.22 (4.46, 19.10)‖ | 3.41 (0.80, 14.63) | |
| Vaginal candidiasis* | 55/269 (20.5%) | 1.52 (0.77, 3.00) | 1.96 (0.49, 7.88) | |
| Herpes simplex PCR on genital swabs | 28/275 (10.2%) | 0.83 (0.30, 2.28) | 1.24 (0.27, 5.75) | |
| Human papilloma virus PCR, any type, in CVL fluid | 109/297 (36.7%) | 1.33 (0.75, 2.36) | 0.52 (0.14, 2.01) | |
| Warts on examination | 38/206 (18.5%) | 1.75 (0.82, 3.75) | 1.83 (0.41, 8.21) | |
| Pap smear: ASCUS | 54/297 (18.2%) | 0.95 (0.46, 1.98) | 1.98 (0.41, 9.61) | |
| Pap smear: SIL | 47/297 (15.8%) | 1.77 (0.88, 3.56) | 1.14 (0.21, 6.35) | |
| RBCs in CVL fluid | 210/289 (72.7%) | 0.88 (0.47, 1.65) | 0.46 (0.12, 1.71) | |
| White blood cells in CVL fluid | 261/289 (90.3%) | 1.21 (0.44, 3.33) | 0.98 (0.12, 8.30) |
ASCUS, atypical squamous cells of uncertain significance; SIL, squamous intraepitheliar lesion.
*
The combination of vaginal discharge on examination and a positive culture for Candida.
†
Nugent score: intermediate versus normal flora (P = 0.0025).
‡
Nugent score: BV versus normal flora (P < 0.0001).
§
Vaginal discharge (P = 0.0030).
¶
Trichomonas (P = 0.0064).
‖
pH (P < 0.0001).
#
Nugent score: intermediate versus normal flora (P = 0.0450).
**
Nugent score: BV versus normal flora (P = 0.0107).
††
Nugent score: intermediate versus normal flora (P = 0.171).
‡‡
Nugent score: BV versus normal flora (P < 0.0001).