TABLE 3.
Crude and Adjusted Association of Cervicovaginal HIV-1 Shedding with HIF in CVL Fluid from HIV-1–Infected Women
| Cervicovaginal HIV-1 Shedding* | ||
|---|---|---|
| Association | OR (95% CI) | P |
| Unadjusted | ||
| HIF activity† | ||
| Heat stable‡ | 2.48 (1.21–5.08) | 0.0134 |
| Heat labile§ | 1.44 (0.81–2.56) | 0.2167 |
| Heat induced¶ | 1.82 (0.16–20.72) | 0.6277 |
| No activity | 1.00 | |
| Adjusted | ||
| HIF activity† | ||
| Heat stable‡ | 1.52 (0.65–3.52) | 0.3324 |
| Heat labile§ | 1.09 (0.55–2.16) | 0.8024 |
| Heat induced¶ | 1.37 (0.10–19.10) | 0.8164 |
| No activity | 1.00 | |
| Log10 Plasma HIV-1 RNA | 5.32 (3.28–8.64) | 0.0001 |
At least 1 genital tract specimen (CVL fluid, swab, or cytobrush) positive for HIV-1 (by RNA detection or culture) indicated genital tract HIV-1 shedding.
HIF activity as ≥600 pg/mL of p24 antigen in supernatant fluids of HIV-1 cultures after the addition of CVL fluid sample.
HIF activity that persists after CVL fluid heating compared with CVL fluid samples lacking HIF activity before and after heating.
HIF activity that decreases below the cutoff value after CVL fluid heating compared with CVL fluid lacking HIF activity before and after heating.
HIF activity that appeared only after CVL fluid heating compared with CVL fluid samples lacking HIF activity before and after heating.