Skip to main content
. Author manuscript; available in PMC: 2012 Jun 10.
Published in final edited form as: Mol Cell. 2011 Jun 10;42(5):624–636. doi: 10.1016/j.molcel.2011.03.031

Figure 7. Cdk2as: a 3-position switch to regulate R-point passage with small molecules.

Figure 7

Cdk2as has activation defects in untreated cells, leading to lower abundance of Cdk2/cyclin A complexes and impaired R-point control. From this partially active state, Cdk2as can be turned ON or OFF, respectively, with the small molecules 6-BAP or 3-MB-PP1—both of which correct conformation, but with opposite effects on catalytic activity—to uncover a rate-limiting role of Cdk2 in pocket protein phosphorylation, R-point passage and S-phase entry.